Endocrine Abstracts

Introduction: Metreleptin, a recombinant analogue of leptin, is the only drug available for the treatment of generalized or partial lipodystrophy. Familial partial lipodystrophy (FPL) is a rare genetic disorder characterized by selective loss of subcutaneous adipose tissue, ectopic fat deposition, decreased leptin levels, and varying metabolic disorders, which in some patients can be quite severe and life-threatening. We present here such a woman with FPL who is treated with m...

Introduction: Pituicytoma is a rare, primary benign, tumor of the sellar and suprasellar regions which is arising from pituicytes of the neurohypophysis and infundibulum and mainly affects middle age adults. We present here such a casePresentation: A 64-years-old man was referred to our clinic. For further investigation of a sellar lesion with suprasellar extension. The patient underwent investigations due to visual disturbances which he noticed initiall...

Introduction: Hypophysitis is a rare entity, more common in women in pregnancy and the postpartum period and can cause various symptoms such as headache, hypopituitarism and visual disturbances. Stalk thickening and homogeneous enhancement of the gland are the characteristic magnetic resonance imaging (MRI) findings. The diagnosis is based on the clinical picture and on follow up MRIs. Usually involves the anterior pituitary alone, whereas isolated-posterior-pituitary-involvem...

Introduction: Obesity is rising worldwide and the number overweight or obese patients with type 1 diabetes mellitus (T1DM) is increased and eating habits (EH) and physical activity (PA) play an important role on glycemic control and weight gain. The aim of the present study was to examine the EH and the exercise level in patients with T1DM and their relation to body weight.Methods: 126 patients with T1DM (55/126 males, 71/126 females) attending our outpa...

Introduction: Aniridia is a rare congenital condition which is characterized by a complete or partial absence of the iris and fovea and malformations of the lens and anterior chamber. It is usually related to mutations in PAX6, a member of a multigene family of transcription factors, which is important for the development of the nervous system, the eyes and also the endocrine pancreas and it is found to be associated with mild glucose intolerance. Complete loss of insulin secr...

Introduction: Pancreatic diabetes is a special category of diabetes due to diseases of the exocrine pancreas, characterized by both insulin and glucagon deficiency and clinically could be very challenging to control. We present a case of a woman with pancreatic diabetes treated with sensor augmented pump therapy after undergoing total pancreatectomy for a nonfunctional pancreatic neuroendocrine tumor (NET).Presentation: A sixty-one years old woman underw...

Introduction: Tertiary hyperparathyroidism can be developed in cases of persistent or non-curable secondary hyperparathyroidism or in any other case of long-standing hypocalcemia that leads to the autonomous function of at least one parathyroid gland. We present a case of a man with tertiary hyperparathyroidism and excessive maxilla swelling and extensive bone lesions.Presentation: A 32 years old man, with chronic renal failure on dialysis for twelve yea...

Introduction: Adrenal cystic lesions are rare. Differential diagnoses include pseudocysts, echinococcal cysts, hemangiomas, cystic pheochromocytomas, adrenal hematomas and lymphangiomas. We present here a rare case of an adrenal lymphangioma.Case report: A 35-year old man was referred to our department for investigation of a right adrenal cystic mass, incidentally found during an abdominal ultrasound. The patient was completely asymptomatic and had a med...

Introduction: Acromegaly is a systematic disease with charecteristic clinical features, which is due to GH hypersecretion mainly from pituitary adenomas and in rare cases it can be due to ectopic GHRH and GH hypersecretion. Sometimes localizing the source of hypersecretion is difficult. Here we present a case of a woman with acromegalic phenotype and empty sella.Presentation: A 47 years old woman referred to our department after recent onset of high bloo...